A Bone to Pick with Compulsive Behavior
نویسنده
چکیده
Mice with mutations in the Hoxb8 gene exhibit compulsive grooming behavior. Chen et al. (2010) now report that this behavior stems from Hoxb8 deficiency in microglia, a type of immune cell in the brain derived from bone marrow. These findings provide intriguing connections between immune dysfunction and neuropsychiatric disorders.
منابع مشابه
Hematopoietic Origin of Pathological Grooming in Hoxb8 Mutant Mice
Mouse Hoxb8 mutants show unexpected behavior manifested by compulsive grooming and hair removal, similar to behavior in humans with the obsessive-compulsive disorder spectrum disorder trichotillomania. As Hox gene disruption often has pleiotropic effects, the root cause of this behavioral deficit was unclear. Here we report that, in the brain, Hoxb8 cell lineage exclusively labels bone marrow-d...
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عنوان ژورنال:
- Cell
دوره 141 شماره
صفحات -
تاریخ انتشار 2010